The CAD Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CAD. This antibody recognizes Human antigen. The CAD Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Subunit Structure: Homohexamer (PubMed:24332717). Interacts with CIPC (PubMed:26657846).
Post-translational Modifications: Activated by MAP kinase (Erk1/2) phosphorylation just prior to the S phase of the cell cycle, when the demand for pyrimidine nucleotides is greatest, and down-regulated as the cells emerge from S phase by protein kinase A (PKA) phosphorylation. Phosphorylation at Ser-1859 by RPS6KB1 downstream of MTOR promotes oligomerization and stimulates dihydroorotase activity. Phosphorylation at Ser-1406 reduces sensitivy to feedback inhibition by UTP.
Similarity: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily